Tubulointerstitial Nephritis and Uveitis Syndrome (TINU)

Standardization of Uveitis Nomenclature Criteria 2021

1. Anterior uveitis with our without intermediate/posterior involvement
   1. Anterior chamber cell
   2. If vitritis, choroiditis or retinal vasculitis anterior chamber inflammation is also present
2. Tubulointerstitial nephritis
   1. Biopsy proven -OR-
   2. Elevated urine β-2 microglobulin -AND-
   3. Abnormal urinalysis or elevated creatinine

• Positive Syphilis serology
• Evidence of Sarcoidosis
  • bilateral hilar adenopathy -OR-
  • tissue biopsy with non-caseating granulomata

• Up to 32% in those with sudden onset bilateral anterior uveitis
• In those with biopsy proven tubulointerstitial nephritis, 46% had uveitis but 84% if they were screened at the outset, then 3 and 6 months later.(3)
  • Saarela V et al Tubulointerstitial nephritis and uveitis syndrome in children: a prospective multicenter study. Ophthalmology. 2013;120(7):1476–1481.

1. Tubulointerstitial Nephritis and Uveitis Syndrome in Pediatric Patients. Janetos TM et al. Ocular Immunology and Inflammation. 2023;31(10):1955-1964
2. Standardization of Uveitis Nomenclature (SUN) Working Group. Classification Criteria for tubulointerstitial nephritis with uveitis syndrome. Am J Ophthalmol. 2021;228:225-261
3. Saarela V et al Tubulointerstitial nephritis and uveitis syndrome in children: a prospective multicenter study. Ophthalmology. 2013;120(7):1476–1481.