Tubulointerstitial Nephritis and Uveitis Syndrome (TINU)

Standardization of Uveitis Nomenclature Criteria 2021

1. Anterior uveitis with our without intermediate/posterior involvement
   1. Anterior chamber cell
   2. If vitritis, choroiditis or retinal vasculitis anterior chamber inflammation is also present
2. Tubulointerstitial nephritis
   1. Biopsy proven -OR-
   2. Elevated urine β-2 microglobulin -AND-
   3. Abnormal urinalysis or elevated creatinine

• Positive Syphilis serology
• Evidence of Sarcoidosis
  • bilateral hilar adenopathy -OR-
  • tissue biopsy with non-caseating granulomata

• Tubulointerstitial Nephritis and Uveitis Syndrome in Pediatric Patients. Janetos TM et al. Ocular Immunology and Inflammation. 2023;31(10):1955-1964
• Standardization of Uveitis Nomenclature (SUN) Working Group. Classification Criteria for tubulointerstitial nephritis with uveitis syndrome. Am J Ophthalmol. 2021;228:225-261