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Genetics of Iris Color
- Eye color is determined by the presence and degree of melanin pigment in the iris
- The degree of pigmentation is a polygenic trait
Genes responsible for iris pigmentation
OCA2
- 75% of variance is from the OCA2 gene(chromosome 15)
- single base change rs12913832 T/C within intron 86 of the upstream HERC2 locus explains almost all of the OCA gene iris pigmentation variation