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Eyelash Poliosis

FIXME

Causes

  • Idiopathic- diagnosis of exclusion
  • Vitiligo
    • acquired pigmentary disorder of skin and hair with depigmented skin patches
    • frequently associated with other autoimmune conditions.
  • Chronic blepharitis
  • Post-inflammatory change from atopic or contact dermatitis especially if there is a history of eczema or dermatitis involving the periocular region.
  • Drug-induced
    • topical prostaglandin F(2α) analogues used for glaucoma, usually reversible poliosis
  • Skin lesions
    • Cutaneous/ocular malignant melanoma may rarely present with poliosis due to destruction of melanocytes adjacent to a melanoma; biopsy is required for diagnosis
    • Halo nevus or other benign nevus-associated poliosis
      • localized whitening of lashes adjacent to a melanocytic nevus.
  • Uveitis associated poliosis
    • Phthisis bulbi
    • Vogt–Koyanagi–Harada (VKH) disease
      • a multisystem autoimmune disorder
      • bilateral granulomatous uveitis, auditory symptoms, and meningeal signs.
    • Sympathetic ophthalmia is a bilateral granulomatous uveitis

Resources

  1. Vitiligo: A Comprehensive Overview Part I. Introduction, Epidemiology, Quality of Life, Diagnosis, Differential Diagnosis, Associations, Histopathology, Etiology, and Work-Up. Alikhan A, Felsten LM, Daly M, Petronic-Rosic V.Journal of the American Academy of Dermatology. 2011;65(3):473-491.
  2. Atopic Dermatitis.Ständer S. The New England Journal of Medicine. 2021;384(12):1136-1143.
  3. Topical Prostaglandin F(2alpha) Analog Induced Poliosis. Chen CS, Wells J, Craig JE. American Journal of Ophthalmology. 2004;137(5):965-6.
  4. Poliosis Circumscripta: Overview and Underlying Causes. Sleiman R, Kurban M, Succaria F, Abbas O. Journal of the American Academy of Dermatology. 2013;69(4):625-33.
  5. Precise, Simplified Diagnostic Criteria and Optimised Management of Initial-Onset Vogt-Koyanagi-Harada Disease: An Updated Review. Herbort CP, Tugal-Tutkun I, Abu-El-Asrar A, et al. Eye (London, England). 2022;36(1):29-43.
  6. Recent Advances in Diagnosis and Management of Sympathetic Ophthalmia. Fromal OV, Swaminathan V, Soares RR, Ho AC. Current Opinion in Ophthalmology. 2021;32(6):555-560.
  7. Guidelines of Care for the Management of Primary Cutaneous Melanoma. Swetter SM, et al. Journal of the American Academy of Dermatology. 2019;80(1):208-250.