Skeletal — rib anomalies (fused, missing, or cervical ribs), mild vertebral anomalies (~9%), painful joints in adults
CNS — Chiari I malformation, cranial nerve palsies (CN VI, VII), hypoplasia of the corpus callosum
Developmental/behavioral — developmental delay and learning difficulties in ~15%; ADHD in some children; adults typically do not have significant intellectual disability
Endocrine — congenital hypothyroidism, growth hormone deficiency (rare)
Other — hemifacial microsomia, postnatal growth deficiency (6–29% reported)