Pediatric Blepharokeratoconjunctivitis (PBKC)

from PBKC Study group, “Pediatric Blepharokeratoconjunctivis is an underdiagnosed, sight-threatening, chronic, and recurrent inflammatory ocular surface disease affecting children and adolescents. Its clinical spectrum includes chronic blepharitis, meibomitis, conjunctivitis, and corneal involvement ranging from superficial punctate keratitis (SPK) to corneal infiltrates with vascularization and scarring”
Results in corneal leukoma, irregular astigmatism, corneal perforation and permanent vision loss.
a.k.a. Staphylococcal blepharokeratoconjunctivitis, Ocular rosacea, Meibomitis- related keratoconjunctivitis, phlyctenular keratoconjunctivitis.

Presumed immunologic response to ocular surface antigens from bacteria (staphylococcus, cutibacterium, mycobacteria) or other agents or organisms (demodex)

Azithromycin
- PO 250-500 mg thrice weekly for 4-8 weeks (5-10 mg/kg)
- Topical: Azasite 1% ophthalmic solution most useful in maintenance of remission
Erythromycin
- PO 250-500 mg QD or BID x 4-8 weeks
- Topical: 0.5% ointment, most helpful for maintaining remission
Doxycycline in children over 8 with their adult teeth.
- Low dose: 40 mg QD or 20 mg BID x 4-8 weeks
- Regular dose: 100 mg QD x 4-8 weeks

Tea Tree Oil 50% eyelid scrubs daily
- Amazon search results
Xdemvy drops (lotilaner ophthalmic solution 0.25%) BID x 6 weeks
- Send to BlinkRx Phone: 1-833-919-4942 Fax: 1-866-585-4631 12639 W Explorer Dr, Suite 100 Boise, ID 83713 NPI #: 1891461885