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sympathomimetic_eyedrops [2015/06/12 03:35] – [Sympathomimetic eyedrops and their mechanism of Action on the Iris] adminsympathomimetic_eyedrops [2025/04/18 20:40] (current) – external edit 127.0.0.1
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 +====== Sympathomimetic eyedrops and their mechanism of action on the Iris ======
  
 +==== Alpha-1 Adrenergic Agonists ===
 +
 +  * cause vasoconstriction, mydriasis and uterine contractions
 +    * Phenylepherine (neoynepherine): Alpha-1 receptor agonist
 +    * Other similar drugs: Dipivefrin, naphazoline
 +
 +==== Alpha-2 adrenergic agonists ====
 +  * have more effects on CNS
 +    * Apraclonadine: weakly binds to Alpha-1 receptors
 +      * Will cause dilation in Horner syndrome pupil due to this binding effect and upregulation of the receptor that occurs 2-5 days after sympathetic block 
 +    * Bromonidine (Alphagan P) is similar with less Alpha-1 effect on pupil
 +
 +==== Indirect Acting Agents ====
 +  * Cocaine: blocks reuptake of norepinephrine 
 +    * causes dilation in normal pupil but not in a Horner syndrome pupil
 +  * Amphetamine: causes release of and blocks reuptake of norepinepherine
 +    * causes dilation in normal pupil but not in a Horner syndrome pupil. 
 +
 +{{tag>drugs}}