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sotos_syndrome [2025/07/01 23:08] Scott Larsonsotos_syndrome [2025/07/01 23:13] (current) – [Main Features] Scott Larson
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   * Distinctive Facial Features   * Distinctive Facial Features
     * Broad, prominent forehead with a dolichocephalic head shape, sparse frontotemporal hair,downslanting palpebral fissures, malar flushing, long and narrow face, tall chin      * Broad, prominent forehead with a dolichocephalic head shape, sparse frontotemporal hair,downslanting palpebral fissures, malar flushing, long and narrow face, tall chin 
-    * {{:sotos_syndrome.jpg |}}+<WRAP round box 60%> 
 +{{:sotos_syndrome.jpg |}} \\ 
 +From Reference 2 \\ 
 +</WRAP>
   * Learning disability   * Learning disability
   * Overgrowth > 2 SD above the mean (98th percentile)   * Overgrowth > 2 SD above the mean (98th percentile)
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   * 5q35 microdeletion encompasing NDS1   * 5q35 microdeletion encompasing NDS1
 ====Resources==== ====Resources====
-  [[https://www.ncbi.nlm.nih.gov/books/NBK1479/|GeneReviews Article]]+  [[https://www.ncbi.nlm.nih.gov/books/NBK1479/|GeneReviews Article]] 
 +  - [[https://1drv.ms/b/c/31d83ae8e55e0542/ERAf3o98dU5Pg3q0-0ZGuNABGuqSz-t3L3IZ3NkB5FygsQ?e=CHzckN |Tatton-Brown K. et al. Clinical Features of NSD1-Positive Sotos Syndrome. Clinical Dysmorphology 2004;13:199-204.]] 
  
 {{tag>syndrome}} {{tag>syndrome}}