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| neuroblastoma [2016/03/22 23:51] – Scott Larson | neuroblastoma [2025/04/18 20:40] (current) – external edit 127.0.0.1 | ||
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| + | ====== Neuroblastoma ====== | ||
| + | * 2-3% of patients with neuroblastoma have opsoclonus-myoclonus-ataxia syndrome | ||
| + | * 50% of those with [[opsoclonus|opsoclonus]] have neuroblastoma | ||
| + | * Children with or without tumors cannot be distinguished by neurologic symptoms | ||
| + | ===== Associated symptoms ===== | ||
| + | * Myoclonus | ||
| + | * Ataxia | ||
| + | * drooling | ||
| + | * refusal to walk or sit | ||
| + | * speech problems | ||
| + | * decreased muscle tone | ||
| + | * rage attacks | ||
| + | * inability to sleep | ||
| + | ===== Survival ===== | ||
| + | * 100% at 3 years in those presenting with [[opsoclonus|opsoclonus]] | ||
| + | * 78% in those presenting with [[horner_syndrome_and_cocaine|Horner syndrome]] | ||
| + | * 11% in those with orbital metastasis | ||
| + | ===== Late problems ===== | ||
| + | * [[opsoclonus|Opsoclonus]] typically resolves | ||
| + | * Cognitive and speech delays | ||
| + | * Motor problems: | ||
| + | * Cerebellar atrophy on later MRI | ||
| + | ===== Etiology ===== | ||
| + | Tumor producing peptide that is neurotoxic to oculomotor system or anticerebellar antibody | ||