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| + | ====== Methotrexate ====== | ||
| + | ===== Mechanism of Action ===== | ||
| + | |||
| + | * Class: Antimetabolite | ||
| + | * Inhibits nucleic acid synthesis and by so doing, it inhibits cell proliferation | ||
| + | * Folate analogue and inhibits dihydrate folate reductase | ||
| + | |||
| + | ===== Dosing and route of administration ===== | ||
| + | * 7.5 to 25 mg once per week | ||
| + | * must also give folic acid | ||
| + | * Has been used via intravitreal injection | ||
| + | * Hardwig PW, Pulido JS, Erie JC, Baratz KH, Buettner H. Intraocular methotrexate in ocular diseases other than primary central nervous system lymphoma. Am J Ophthalmol. 2006 Nov; 142(5): | ||
| + | * Taylor SR, Habot-Wilner Z, Pacheco P, Lightman SL. Intraocular methotrexate in the treatment of uveitis and uveitic cystoid macular edema. Ophthalmology. 2009 Apr; 116(4): | ||
| + | ===== Side Effects ===== | ||
| + | * Hepatotoxicity- Liver function should be monitored | ||
| + | * Cytopenia | ||
| + | * Interstitial Pneumonitis | ||
| + | * Teratogen | ||
| + | |||
| + | {{tag> | ||