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| hereditary_optic_neuropathies [2017/02/20 01:52] – [Hereditary Optic Neuropathies without other systemic signs] hstiff | hereditary_optic_neuropathies [2025/04/18 20:40] (current) – external edit 127.0.0.1 | ||
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| * symmetric, bilateral, painless, usually permanent, central visual loss | * symmetric, bilateral, painless, usually permanent, central visual loss | ||
| * affects papillomacular nerve fiber bundle -> central/ | * affects papillomacular nerve fiber bundle -> central/ | ||
| + | * May present with other ophthalmologic, | ||
| ===== Differential ===== | ===== Differential ===== | ||
| + | ==== Optic Neuropathies WITHOUT other systemic signs ==== | ||
| + | |||
| * Leber Hereditary Optic Neuropathy | * Leber Hereditary Optic Neuropathy | ||
| * point mutations in mitochondrial DNA, predominately males age 15-35, second eye affected within 1 year of first eye affected, pseudoedema and optic atrophy can be seen on exam | * point mutations in mitochondrial DNA, predominately males age 15-35, second eye affected within 1 year of first eye affected, pseudoedema and optic atrophy can be seen on exam | ||
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| * Autosomal Recessive Optic Atrophy | * Autosomal Recessive Optic Atrophy | ||
| * discovered before 3-4 years old, consanguinity between parents, severely reduced visual acuity (may have sensory nystagmus), optic discs atrophic and deeply cupped | * discovered before 3-4 years old, consanguinity between parents, severely reduced visual acuity (may have sensory nystagmus), optic discs atrophic and deeply cupped | ||
| + | ===== References ===== | ||
| + | Taylor and Hoyt's Pediatric Ophthalmology and Strabismus, Fifth Edition. // | ||