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doxycycline [2025/07/11 22:48] – created Scott Larsondoxycycline [2025/11/03 16:00] (current) – [Side Effects] Scott Larson
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   * 40-200 mg/day have been used   * 40-200 mg/day have been used
     * most evidence for 100 mg QD x 3 months or 50 mg QD x 8 months      * most evidence for 100 mg QD x 3 months or 50 mg QD x 8 months 
 +    * 20 mg tabs BID x 8 weeks may have less side effects
   * Duration: 4 weeks to 8 months    * Duration: 4 weeks to 8 months 
 ===== Side Effects ===== ===== Side Effects =====
-  * Skin: photosensitivity and lesions +  * Skin: maculopapular and erythematous rash, photosensitivity and lesions  
-  * GI: emesis, diarrhea, dyspepsia  +    * Stevens-Johnsons syndrome rare 
-  * Stevens-Johnsons syndrome+  * GI: (most common) nausea, emesis, diarrhea, glossitis, esophagitis dysphagia, dyspepsia enterocolitis, rarely pancreatitis  
 +  * Hepatotoxicity, dose related rise in BUN 
 +  * Renal toxicity  
 +  * Blood: hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia 
 +  * CNS: Intracranial hypertension 
 +  * Discolorations:  tooth enamel- maybe permanent in primary teeth,  reversable in adult teeth.  Browning of the thyroid gland (microscopic) without functional problems.  
 +  * Psychiatric: depression, anxiety, suicidal ideation, insomina, hallucinations, abnormal dreams.  
   * Supratheraputic INR in those taking coumadin    * Supratheraputic INR in those taking coumadin 
 ===== Contraindications ===== ===== Contraindications =====