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behcet_disease [2026/02/04 22:40] – [Other Findings] Scott Larsonbehcet_disease [2026/02/04 22:46] (current) – [Etiology] Scott Larson
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 ====== Behçet's Disease ====== ====== Behçet's Disease ======
-FIXME+
 ====Main Features==== ====Main Features====
   *  Systemic Vasculitis characterized by recurrent oral ulcers (nearly all) with variable involvement of skin, eyes, joints, vascular system, GI tract and CNS   *  Systemic Vasculitis characterized by recurrent oral ulcers (nearly all) with variable involvement of skin, eyes, joints, vascular system, GI tract and CNS
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     * Hemorrhage and/or perforation      * Hemorrhage and/or perforation 
 ====Etiology==== ====Etiology====
-  * +  * Genetically predisposed are exposed to environmental triggers leading to activation of cellular signally pathways leading to tissue inflammation and damage.  
 +  * HLA B*51 increases the risk by 6 
 +  * Highest prevalence in Turkey: 420 cases per 100,000 
 +  * US: 5.2 cases per 100,000 
 ====Resources==== ====Resources====
   * [[https://www.nejm.org/doi/full/10.1056/NEJMra2305712?utm_source=openevidence|Behçet's Syndrome. Saadoun D et al. N Engl J Med 2024;390:640-651]]   * [[https://www.nejm.org/doi/full/10.1056/NEJMra2305712?utm_source=openevidence|Behçet's Syndrome. Saadoun D et al. N Engl J Med 2024;390:640-651]]